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GNE7915 | Competitive of LRRK2
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

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Targets Biochemical/Biophysical Potency Cellular Potency
LRRK2
  • Ki(app):1 nM
  • IC50:9 nM
Competitive
Up to 100 nM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
In vitro kinase assays, GNE7915 inhibited only 1 kinase >50% at 0.1 uM. In DiscoveRx Kinome scan of ...

Potency
Cellular
In Vitro

LRRK2

Mode of Action: Competitive

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/jm301020q

In Vivo Validations

Rat
Dose: 0.5 mg/kg
Route of delivery: Intravenous
Plasma half life: 3.1 hr
Systemic clearance: 8.3 mL/min/kg
Organ of interest (O): brain
Target engagement assay: Indirect: inhibition of autophosphorylation

DOI Reference: 10.1021/jm301020q

Orthogonal Probes def

MLi-2

Chemical Information

Molecular Formula C19H21F4N5O3
SMILEs CCNc1nc(Nc2cc(F)c(C(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F
InChI InChI=1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)
Molecular weight 443.16 Da
AlogP 3.2909000000000024
HBond acceptors 8
HBond donors 2
Atoms 52

References

Publications

Cross References

ChEMBL BindingDB PDB PubChem PROTAC-DB canSAR

Vendors

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Expert Reviews

by SERP
(on 15 Jun 2016)
Cellular Use Rating
In Model Organisms
In vivo use will depend on application and delivery method: 15 mg/kg is suitable for IP, and 50 mg/kg suitable for oral delivery.
by SERP
(on 6 Sept 2016)
Cellular Use Rating
In Model Organisms
This probe comes from a structure- and property-guided optimization of an earlier compound that was identified using a JAK2-based LRRK2-homology model. As such, JAK2 was used for selectivity standard...
by SERP
(on 30 Mar 2017)
Cellular Use Rating
In Model Organisms
This reviewer would use GNE7915 in the cell-based setting with caution. The reasons are several fold: 1) Only biochemical selectivity was disclosed in the paper - no translation to selectivity in cell-based...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria