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GNE-049 | Inhibitor of CREBBP, EP300
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CREBBP
  • IC 50:1.1 nM
  • IC 50:12 nM
  • EC 50:13.8 nM
EP300
  • IC 50:1.3 nM
    Inhibitor
    100 nM

    Selectivity

    In Vitro Selectivity Assessment
    Selectivity Assessment Description:
    BromoScan highlight KD BRDT 1.4 uM

    Potency
    Cellular
    In Vitro

    CREBBP

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1021/acs.jmedchem.7b00796

    EP300

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1021/acs.jmedchem.7b00796

    In Vivo Validations

    Mouse (M), Rat (R), Dog (D), Cyno (C)
    Dose: 1 mg/Kg IV, 5 mg/Kg PO
    Route of delivery: Intravenous, Oral
    Plasma half life: 1.1 (M), 0.66 (R), 4.2 (D), 2.8 (C) h
    Systemic clearance: 8.8 (M), 16 (R), 4.6 (D), 7.4 (C) mL/min/Kg

    DOI Reference: 10.1021/acs.jmedchem.7b00796

    Orthogonal Probes def

    SGC-CBP30
    I-CBP112

    Chemical Information

    Molecular Formula C27H32F2N6O2
    SMILEs CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1
    InChI InChI=1S/C27H32F2N6O2/c1-17(36)33-9-5-24-23(16-33)27(31-35(24)20-6-10-37-11-7-20)34-8-3-4-18-12-21(19-14-30-32(2)15-19)22(26(28)29)13-25(18)34/h12-15,20,26H,3-11,16H2,1-2H3
    Molecular weight 510.26 Da
    AlogP 4.5616
    HBond acceptors 8
    HBond donors --
    Atoms 69
    PAINS * Yes

    * This is an automated alert only, and may not necessarily indicate an issue with this probe. ( Learn more about PAINS )

    Vendors

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    Expert Reviews

    by SERP
    (on 24 Mar 2021 )
    Cellular Use Rating
    In Model Organisms
    GNE-049 has been studied in various cellular assays and is a potent, selective, cell-penetrant probe. It has also been evaluated in preliminary PK studies in 4 species (mouse, rat, dog, cyno) and studied...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria