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GI254023X | Inhibitor of ADAM10
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
ADAM10
  • IC50:5.3 nM
  • IC50:1500 nM
  • IC50:400 nM
  • IC50:1800 nM
Inhibitor
up to 10 uM

Selectivity

In Vitro Selectivity Assessment

Potency: IC50

Selectivity Assessment Description:
100 fold selective over ADAM17 (541 nM): <p> Selectivity over other Recombinant MMPs 1 / 3 / ...

Potency
Cellular
In Vitro

ADAM10

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.2174/1386207053258488

In Vivo Validations

Mouse
Dose: 100 mg/Kg
Route of delivery: Intraperitoneal

Reference: --

Chemical Information

Molecular Formula C21H33N3O4
SMILEs CNC(=O)[C@@H](NC(=O)[C@H](CCCc1ccccc1)[C@H](C)N(O)C=O)C(C)(C)C
InChI InChI=1S/C21H33N3O4/c1-15(24(28)14-25)17(13-9-12-16-10-7-6-8-11-16)19(26)23-18(20(27)22-5)21(2,3)4/h6-8,10-11,14-15,17-18,28H,9,12-13H2,1-5H3,(H,22,27)(H,23,26)/t15-,17+,18+/m0/s1
Molecular weight 391.25 Da
AlogP 2.1384999999999987
HBond acceptors 7
HBond donors 3
Atoms 61

References

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Expert Reviews

No SERP comments found for GI254023X

Probe GI254023X is in the process of SERP review.

Please continue to check back for new reviews and commentary.