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Gandotinib | Gandotinib : Inhibitor of JAK2
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
JAK2 (Mutant:WT, V617F)
  • IC50:0.191 nM
  • IC50:0.246 nM
  • IC50:45 nM (T); 942 nM (N); 191 nM (A); 20 nM (S) Mutant; 55 nM (P) Mutant
Inhibitor
up to 200 nM

Selectivity

In Vitro Selectivity Assessment

Potency: IC50 - FLT3 4 nM

Potency Assay Off-Target:
Cerep
Selectivity Assessment Description:
Assessed against a CEREP kinase panel (total of 99 kinases). Of these, 20 kinases were inhibited ...

Potency
Cellular
In Vitro

JAK2 (Mutant:WT, V617F)

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1038/bcj.2013.6

In Vivo Validations

Mouse, Rat
Dose: 30, 60, 100 mg/Kg
Route of delivery: Oral

Reference: --

Orthogonal Probes def

XL019
AZ-960
BMS-911543

Chemical Information

Molecular Formula C23H25ClFN7O
SMILEs Cc1cc(Nc2cc(CN3CCOCC3)c3nc(C)c(Cc4ccc(Cl)cc4F)n3n2)n[nH]1
InChI InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h3-4,9,11-12H,5-8,10,13H2,1-2H3,(H2,27,28,29,30)
Molecular weight 469.18 Da
AlogP 0.0
HBond acceptors 8
HBond donors 2
Atoms 58

References

Publications

Cross References

canSARChEMBLBindingDBPDB

Vendors

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Expert Reviews

by SERP
(on 26 Jul 2021 )
Cellular Use Rating
In Model Organisms
Concentration notes: Data suggests it could be dosed up to 20 uM in cellular assays. BID dosing is required to maintain reasonable drug levels in vivo models. PK parameters are not discussed;...
by SERP
(on 29 Jul 2021 )
Cellular Use Rating
In Model Organisms
Activation of the JAK-STAT signalling pathway has been associated with cancer progression across multiple tumour types either as a tumour intrinsic driver of cancer cell growth and spread or as a modulator...
by SERP
(on 16 Aug 2021 )
Cellular Use Rating
In Model Organisms
The cpd should also be tested in vitro and in vivo against FLT4 and FLT3 driven tumors and Baf3 cells (may be testing of this cpd against a large panel of Baf3 cell (ACD-Baf3) would be more beneficial...
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