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FT671 | FT671 : Inhibitor of USP7
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
USP7
  • Kd:65 nM
  • IC50:52 nM
  • IC50:33 nM
  • INH:0.1 - 2 µM
  • INH:1 µM
Inhibitor
1 to 10 µM
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
FT671 xclusively inhibit USP7 in a panel of 38 deubiquitinases (DUBs) from diverse families at 50 uM ...

Potency
Cellular
In Vitro

USP7

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1038/nature24451

Chemical Information

Molecular Formula C24H23F4N7O3
SMILEs O=C(C[C@@H](C(F)F)n1ccc(F)n1)N1CCC(O)(Cn2cnc3c(cnn3-c3ccc(F)cc3)c2=O)CC1
InChI InChI=1S/C24H23F4N7O3/c25-15-1-3-16(4-2-15)35-22-17(12-30-35)23(37)33(14-29-22)13-24(38)6-9-32(10-7-24)20(36)11-18(21(27)28)34-8-5-19(26)31-34/h1-5,8,12,14,18,21,38H,6-7,9-11,13H2/t18-/m0/s1
Molecular weight 533.18 Da
AlogP 2.3069000000000006
HBond acceptors 10
HBond donors 1
Atoms 61

References

Publications

Cross References

canSARChEMBLBindingDBPDB

Expert Reviews

by SERP
(on 29 Mar 2024 )
Cellular Use Rating
Well-characterized, selective inhibitor of USP7 suitable for use in cellular experiments. The original publication shows an effect in a mouse xenograft model derived from a cell line that is sensitive...
by SERP
(on 9 Apr 2024 )
Cellular Use Rating
The quality of the probe should be tested after long-term storage ensuring it is not degraded, still pure etc
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria