Chemical Probes logo
FB23-2 | FB23-2 : Inhibitor of FTO
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
FTO
  • IC50:2600 ± 500 nM
  • IC50:800-1500 nM
  • Activity:5000 nM
Inhibitor
up to 5 uM

Selectivity

In Vitro Selectivity Assessment

Potency
Cellular
In Vitro

FTO

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

PMID Reference: 30991027

In Vivo Validations

Rat
Dose: 3 mg/kg
Route of delivery: Intraperitoneal
Plasma half life: 6.7 hr
Cmax: 2421 ng/mL
Tmax: 0.08 hr
Area Under the Curve:: 2184 hr x ng/mL

PMID Reference: 30991027

Chemical Information

Molecular Formula C18H15Cl2N3O3
SMILEs Cc1noc(C)c1-c1cc(Cl)c(Nc2ccccc2C(=O)NO)c(Cl)c1
InChI InChI=1S/C18H15Cl2N3O3/c1-9-16(10(2)26-23-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(24)22-25/h3-8,21,25H,1-2H3,(H,22,24)
Molecular weight 391.05 Da
AlogP 5.127840000000003
HBond acceptors 6
HBond donors 3
Atoms 41

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the portal.

Expert Reviews

by SERP
(on 10 Jan 2022)
Cellular Use Rating
In Model Organisms
Considering that the in vitro inhibition of FTO is in the same single digit micromolar range as some of the kinase off-targets, it is important to consider their potential effects in cellular assays. An...
by SERP
(on 22 Jan 2022)
Cellular Use Rating
In Model Organisms
Although compelling data is presented that FB23 and FB-23-2 are binding to FTO, there are significant data disconnects that call into question whether some of the observed phenotypic effects are correlated...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria