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FB23-2 | FB23-2 : Inhibitor of FTO
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
FTO
  • IC50:2600 ± 500 nM
  • IC50:800-1500 nM
  • Activity:5000 nM
Inhibitor
up to 5 uM

Selectivity

In Vitro Selectivity Assessment

Potency
Cellular
In Vitro

FTO

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

PMID Reference: 30991027

In Vivo Validations

Rat
Dose: 3 mg/kg
Route of delivery: Intraperitoneal
Plasma half life: 6.7 hr
Cmax: 2421 ng/mL
Tmax: 0.08 hr
Area Under the Curve:: 2184 hr x ng/mL

PMID Reference: 30991027

Chemical Information

Molecular Formula C18H15Cl2N3O3
SMILEs Cc1noc(C)c1-c1cc(Cl)c(Nc2ccccc2C(=O)NO)c(Cl)c1
InChI InChI=1S/C18H15Cl2N3O3/c1-9-16(10(2)26-23-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(24)22-25/h3-8,21,25H,1-2H3,(H,22,24)
Molecular weight 391.05 Da
AlogP 5.127840000000003
HBond acceptors 6
HBond donors 3
Atoms 41

Vendors

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Expert Reviews

by SERP
(on 10 Jan 2022 )
Cellular Use Rating
In Model Organisms
Considering that the in vitro inhibition of FTO is in the same single digit micromolar range as some of the kinase off-targets, it is important to consider their potential effects in cellular assays. An...
by SERP
(on 22 Jan 2022 )
Cellular Use Rating
In Model Organisms
Although compelling data is presented that FB23 and FB-23-2 are binding to FTO, there are significant data disconnects that call into question whether some of the observed phenotypic effects are correlated...
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