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Ezeprogind | Ezeprogind : Modulator of GRN
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
GRN
  • Kd:201 nM
  • IC50:24 nM
Modulator
100 nM
100 nM, up to 1 uM

Selectivity

Potency
Cellular
In Vitro

GRN

Mode of Action: Modulator

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1038/s41598-021-94708-1

In Vivo Validations

Mouse
Dose:
Route of delivery: Oral

DOI Reference: 10.1038/s41598-021-94708-1

Chemical Information

Molecular Formula C25H44N6
SMILEs CC(C)CN(CCCN1CCN(CCCNc2nc3ccccc3[nH]2)CC1)CC(C)C
InChI InChI=1S/C25H44N6/c1-21(2)19-31(20-22(3)4)14-8-13-30-17-15-29(16-18-30)12-7-11-26-25-27-23-9-5-6-10-24(23)28-25/h5-6,9-10,21-22H,7-8,11-20H2,1-4H3,(H2,26,27,28)
Molecular weight 428.36 Da
AlogP 0.0
HBond acceptors 6
HBond donors 2
Atoms 75

References

Publications

Cross References

canSARChEMBLBindingDB

Vendors

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Expert Reviews

by SERP
(on 13 Mar 2024 )
Cellular Use Rating
In Model Organisms
( The reviewer did not leave any comments )
by SERP
(on 27 May 2024 )
Cellular Use Rating
In Model Organisms
In the original publication the authors state: "Given the multiple actions of AZP2006, more experiments are needed to clearly understand the mechanism underpinning PGRN release and TLR9 inhibition. In...
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