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Ezeprogind | Ezeprogind : Modulator of GRN
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
GRN
  • Kd:201 nM
  • IC50:24 nM
Modulator
100 nM
100 nM, up to 1 uM

Selectivity

Potency
Cellular
In Vitro

GRN

Mode of Action: Modulator

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1038/s41598-021-94708-1

In Vivo Validations

Mouse
Dose:
Route of delivery: Oral

DOI Reference: 10.1038/s41598-021-94708-1

Chemical Information

Molecular Formula C25H44N6
SMILEs CC(C)CN(CCCN1CCN(CCCNc2nc3ccccc3[nH]2)CC1)CC(C)C
InChI InChI=1S/C25H44N6/c1-21(2)19-31(20-22(3)4)14-8-13-30-17-15-29(16-18-30)12-7-11-26-25-27-23-9-5-6-10-24(23)28-25/h5-6,9-10,21-22H,7-8,11-20H2,1-4H3,(H2,26,27,28)
Molecular weight 428.36 Da
AlogP 0.0
HBond acceptors 6
HBond donors 2
Atoms 75

References

Publications

Cross References

canSARChEMBLBindingDB

Vendors

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Expert Reviews

by SERP
(on 13 Mar 2024)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
by SERP
(on 27 May 2024)
Cellular Use Rating
In Model Organisms
In the original publication the authors state: "Given the multiple actions of AZP2006, more experiments are needed to clearly understand the mechanism underpinning PGRN release and TLR9 inhibition. In...
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