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ERD-308 | ERD-308 : Degrader (PROTAC) of ESR1
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
ESR1
    • DC50:0.17 nM
    • Dmax:>99%
    • DC50:0.43 nM
    • Dmax:>95%
    • IC50:0.77 nM
    Degrader (PROTAC)
    up to 100 nM

    Selectivity

    Potency
    Cellular
    In Vitro

    ESR1

    Mode of Action: Degrader (PROTAC)

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1021/acs.jmedchem.8b01572

    Orthogonal Probes def

    AZD-9496

    Chemical Information

    Molecular Formula C55H65N5O9S2
    SMILEs CCN(CCCCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1
    InChI InChI=1S/C55H65N5O9S2/c1-7-59(26-28-69-43-22-17-37(18-23-43)49(65)48-44-24-21-41(62)30-46(44)71-51(48)39-15-19-40(61)20-16-39)25-9-8-10-27-68-32-47(64)58-52(55(4,5)6)54(67)60-31-42(63)29-45(60)53(66)57-34(2)36-11-13-38(14-12-36)50-35(3)56-33-70-50/h11-24,30,33-34,42,45,52,61-63H,7-10,25-29,31-32H2,1-6H3,(H,57,66)(H,58,64)/t34-,42+,45-,52+/m0/s1
    Molecular weight 1003.42 Da
    AlogP 8.900120000000005
    HBond acceptors 14
    HBond donors 5
    Atoms 136

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    Expert Reviews

    by SERP
    (on 21 Apr 2022)
    Cellular Use Rating
    (The reviewer did not leave any public comments)
    by SERP+
    (on 31 Oct 2024)
    Cellular Use Rating
    There is no selectivity evaluation by proteomics. in particular, the existence of estrogen receptor B, requires its inclusion in the degradation analysis.
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria