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EMD 1214063 | EMD 1214063 : Inhibitor of MET
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MET
  • IC50:3 nM
  • IC50:6 nM
  • IC50:9 nM
  • IC50:1 nM
Inhibitor
up to 100 nM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Kinase inhibition by EMD 1214063 (1 and 10 μM) was assessed in vitro using a panel of 242 different ...
Selectivity Assessment Description:
Formal IC50 determinations conducted with these kinases resulted in IC50 values ranging from 615 to ...

Potency
Cellular
In Vitro

MET

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1158/1078-0432.CCR-12-3247

In Vivo Validations

Mouse
Dose: 3, 10, 30, and 100 mg/kg
Route of delivery: Oral

DOI Reference: 10.1158/1078-0432.CCR-12-3247

Chemical Information

Molecular Formula C29H28N6O2
InChI InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
Molecular weight 492.23 Da
AlogP 0.0
HBond acceptors 8
HBond donors --
Atoms 65

Expert Reviews

No SERP comments found for EMD 1214063

Probe EMD 1214063 is in the process of SERP review.

Please continue to check back for new reviews and commentary.