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Eleutherobin | Inhibitor of TUBB
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
TUBB
  • EC50:6500 nM
  • EC50:2000 nM
Inhibitor
250-500 nM

Selectivity

Potency
Cellular
In Vitro

TUBB

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

PMID Reference: 9515790

Orthogonal Probes def

PACLITAXEL
TAXOL C

Chemical Information

Molecular Formula C35H48N2O10
SMILEs CO[C@]12C=C[C@](C)(O1)[C@@H](OC(=O)/C=C/c1cn(C)cn1)C[C@H]1C(C)=CC[C@H](C(C)C)[C@H]1/C=C\2CO[C@@H]1OC[C@@H](O)[C@@H](O)[C@@H]1OC(C)=O
InChI InChI=1S/C35H48N2O10/c1-20(2)25-10-8-21(3)26-15-29(46-30(40)11-9-24-16-37(6)19-36-24)34(5)12-13-35(42-7,47-34)23(14-27(25)26)17-43-33-32(45-22(4)38)31(41)28(39)18-44-33/h8-9,11-14,16,19-20,25-29,31-33,39,41H,10,15,17-18H2,1-7H3/b11-9+,23-14-/t25-,26+,27-,28-,29+,31-,32+,33-,34+,35-/m1/s1
Molecular weight 656.33 Da
AlogP 3.244
HBond acceptors 12
HBond donors 2
Atoms 95

References

Publications

Cross References

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Expert Reviews

by SERP
(on 15 May 2020 )
Cellular Use Rating
( The reviewer did not leave any comments )
by SERP
(on 7 Jun 2020 )
Cellular Use Rating
Eleutherobin is the prototypical member of the eleutherobin class of tubulin inhibitors, consisting of 7 unique agents each isolated from several species of marine sponges. Its structure is well defined...
by SERP
(on 4 Nov 2020 )
Cellular Use Rating
Even if the direct activity of eleutherobin on tubulin has been demonstrated in vitro, some structural components are potentially reactive (such as the Michael acceptor) and reversible and/or irreversible...
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