ELAGOLIX |
ELAGOLIX : Antagonist of GNRHR
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| GNRHR |
|
|
Antagonist
up to 100 nM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
Elagolix was highly selective at hGnRH-R, its wider receptor selectivity was tested at a concentrati ...
Potency Cellular
In Vitro
GNRHR
Mode of Action: Antagonist
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/jm8006454
In Vivo Validations
Rat
Dose: 10 mg/kg
Route of delivery:
Intravenous, Oral
Plasma half life:
0.9 h
Systemic clearance:
33.3 mL/(min·kg)
Cmax:
338 ng/mL
Tmax:
0.25 h
Area Under the Curve::
290 ng/(mL·h)
Bioavailability:
5.8%
Volume of Distribution at Steady-State:
2.6 L/Kg
DOI Reference: 10.1021/jm8006454
Mouse
Dose:
Route of delivery:
Intravenous, Oral
Plasma half life:
0.3 h
Systemic clearance:
50 mL/(min·kg)
Cmax:
741 ng/mL
Tmax:
0.25 h
Area Under the Curve::
326 ng/(mL·h)
Bioavailability:
10%
Volume of Distribution at Steady-State:
1.4 L/Kg
DOI Reference: 10.1021/jm8006454
Monkey (Rheus)
Dose:
Route of delivery:
Intravenous, Oral
Plasma half life:
1.1 h
Systemic clearance:
25.7 mL/(min·kg)
Cmax:
518 ng/mL
Tmax:
0.69 h
Area Under the Curve::
699 ng/(mL·h)
Bioavailability:
11%
Volume of Distribution at Steady-State:
2.5 L/Kg
DOI Reference: 10.1021/jm8006454
Dog
Dose: 50 mg/Kg PO
Route of delivery:
Intravenous, Oral
Plasma half life:
2.8 h
Systemic clearance:
14.5 mL/(min·kg)
Cmax:
13900 ng/mL
Tmax:
2 h
Area Under the Curve::
80700 ng/(mL·h)
Bioavailability:
∼100%
Volume of Distribution at Steady-State:
0.92 L/Kg
DOI Reference: 10.1021/jm8006454
Chemical Information
| Molecular Formula | C32H30F5N3O5 |
| InChI | InChI=1S/C32H30F5N3O5/c1-19-28(21-11-6-14-26(45-2)29(21)34)30(43)40(18-25(20-9-4-3-5-10-20)38-16-8-15-27(41)42)31(44)39(19)17-22-23(32(35,36)37)12-7-13-24(22)33/h3-7,9-14,25,38H,8,15-18H2,1-2H3,(H,41,42)/t25-/m0/s1 |
| Molecular weight | 631.21 Da |
| AlogP | 0.0 |
| HBond acceptors | 8 |
| HBond donors | 2 |
| Atoms | 75 |