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DN02 | DN02 : Inhibitor of BRD8
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
BRD8
  • IC50:48 nM
  • Kd:34 nM
  • IC50:640 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Chemoproteomics data showed only BRD8 associated proteins. Selective BD1 over BD2 (Kd >1 uM) in Brom ...

Potency
Cellular
In Vitro

BRD8

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acschembio.1c00256

Chemical Information

Molecular Formula C22H24FN3O3
SMILEs COc1cc(CN2CC(N)C2)cc(OC)c1-c1cn(C)c(=O)c2cc(F)ccc12
InChI InChI=1S/C22H24FN3O3/c1-25-12-18(16-5-4-14(23)8-17(16)22(25)27)21-19(28-2)6-13(7-20(21)29-3)9-26-10-15(24)11-26/h4-8,12,15H,9-11,24H2,1-3H3
Molecular weight 397.18 Da
AlogP 2.5046999999999997
HBond acceptors 6
HBond donors 2
Atoms 53

Expert Reviews

by SERP+
(on 23 Sept 2024 )
Cellular Use Rating
( The reviewer did not leave any comments )
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