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DDD85646 | Inhibitor of NMT1, NMT2
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NMT1
  • IC 50:3 nM
  • Kd:14 nM
  • EC 50:2 nM Tb
NMT2
  • IC50, KD:2 nM TbNMT, 3 nM HsNMT-1, 2 nM LmNMT, 3 nM TcNMT; ; 1 nM TbNMT, 14 nM HsNMT-1 KD
  • EC 50:2 nM Tb
Inhibitor
up to 100 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Not selective across species in vitro (biochemical assay)
In Cell Selectivity Assessment
Selectivity Assessment Description:
DDD85646 shows promising selectivity at the cellular level

Potency
Cellular
In Vitro

NMT1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1038/nature08893

NMT2

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1038/nature08893

In Vivo Validations

Mouse
Dose: 3 mg/Kg IV, 10 mg/Kg PO, up to 50 mg/Kg
Route of delivery: Intravenous, Oral
Plasma half life: 1.2 h
Systemic clearance: 6 mL/min/Kg

DOI Reference: 10.1038/nature08893

Orthogonal Probes def

IMP-1088

Chemical Information

Molecular Formula C21H24Cl2N6O2S
SMILEs Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(-c2ccnc(N3CCNCC3)c2)cc1Cl
InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3
Molecular weight 494.11 Da
AlogP 0.0
HBond acceptors 8
HBond donors 2
Atoms 56

References

Publications

Cross References

canSARChEMBLBindingDBPDBPubMed

Vendors

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Expert Reviews

No SERP comments found for DDD85646

Probe DDD85646 is in the process of SERP review.

Please continue to check back for new reviews and commentary.