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dBRD9 | Degrader (PROTAC) of BRD9
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
BRD9
  • IC50:104 nM
  • EC50:5 nM
  • EC50:90 nM
Degrader (PROTAC)
100 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
BromoScan @ 1uM BRD4 > 50 uM, no off-targets. on detectable degradation of off-targets by west ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
western blot
Selectivity Assessment Description:
no detectable degradation of off-targets

Potency
Cellular
In Vitro

BRD9

Mode of Action: Degrader (PROTAC)

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1002/anie.201611281

Orthogonal Probes def

I-BRD9

Chemical Information

Molecular Formula C40H45N7O10
SMILEs COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)CC(=O)NCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O
InChI InChI=1S/C40H45N7O10/c1-45(21-29-32(54-3)18-24(19-33(29)55-4)28-22-46(2)38(51)27-20-41-11-10-25(27)28)23-35(49)43-13-15-57-17-16-56-14-12-42-30-7-5-6-26-36(30)40(53)47(39(26)52)31-8-9-34(48)44-37(31)50/h5-7,10-11,18-20,22,31,42H,8-9,12-17,21,23H2,1-4H3,(H,43,49)(H,44,48,50)
Molecular weight 783.32 Da
AlogP 0.0
HBond acceptors 17
HBond donors 3
Atoms 102

References

Publications

Cross References

canSARChEMBLBindingDB

Vendors

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Expert Reviews

by SERP
(on 19 Jan 2021 )
Cellular Use Rating
( The reviewer did not leave any comments )
by SERP
(on 9 Feb 2021 )
Cellular Use Rating
( The reviewer did not leave any comments )
by SERP
(on 18 Feb 2021 )
Cellular Use Rating
( The reviewer did not leave any comments )
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