DAPORINAD |
DAPORINAD : Inhibitor of NAMPT
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| NAMPT |
|
|
Inhibitor
up to 100 nM
Selectivity
In Cell Selectivity Assessment
Selectivity Assessment Description:
Clonogenic Assay in a Selection of Cancer Cell Lines shows little selectivity for DAPORINAD DOI: 10 ...
Potency Cellular
In Vitro
NAMPT
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? Yes
PMID Reference: 14612543
In Vivo Validations
Mouse
Dose: 5 mg/Kg
Route of delivery:
Intravenous
Plasma half life:
52.9 min
Systemic clearance:
29.29 mL/min/kg
Cmax:
5476.2 ng/mL
Area Under the Curve::
171,690 min∙ng/mL
Volume of Distribution at Steady-State:
897.1 mL/Kg
DOI Reference: 10.3390/molecules27062011
Dose: 10 mg/Kg
Route of delivery:
Intravenous
Plasma half life:
50.5 min
Systemic clearance:
28.1 mL/min/kg
Cmax:
14,872 ng/mL
Area Under the Curve::
357,205 min∙ng/mL
Volume of Distribution at Steady-State:
646.6 mL/Kg
DOI Reference: 10.3390/molecules27062011
Dose: 30 mg/Kg
Route of delivery:
Intravenous
Plasma half life:
40.8 min
Systemic clearance:
17.9 mL/min/kg
Cmax:
48,059 ng/mL
Area Under the Curve::
1,763,266 min∙ng/mL
Volume of Distribution at Steady-State:
535.8 mL/Kg
DOI Reference: 10.3390/molecules27062011
Chemical Information
| Molecular Formula | C24H29N3O2 |
| SMILEs | O=C(/C=C/c1cccnc1)NCCCCC1CCN(C(=O)c2ccccc2)CC1 |
| InChI | InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+ |
| Molecular weight | 391.23 Da |
| AlogP | 3.9337000000000035 |
| HBond acceptors | 5 |
| HBond donors | 1 |
| Atoms | 58 |
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