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Danusertib | Danusertib : Inhibitor of AURKA, AURKB, AURKC
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
AURKA
  • Ki:2.5 nM
  • IC50:13 nM
  • IC50:28-140 nM
AURKB
  • IC50:79 nM
    AURKC
    • IC50:61 nM
      Inhibitor
      up to 1 uM

      Selectivity

      In Vitro Selectivity Assessment
      Selectivity Assessment Description:
      Danusertib inhibits an additional set of protein kinases, namely, ABL, RET, TRKA, and FGFR1 in the n ...

      Potency
      Cellular
      In Vitro

      AURKA

      Mode of Action: Inhibitor

      Structure-Activity-Relationship data available? Yes

      DOI Reference: 10.1021/jm060897w

      AURKB

      Mode of Action: Inhibitor

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1021/jm060897w

      AURKC

      Mode of Action: Inhibitor

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1021/jm060897w

      In Vivo Validations

      Mouse
      Dose: 10 mg/Kg
      Route of delivery: Intravenous
      Plasma half life: 1.4 h
      Systemic clearance: 3.6 L/h/kg
      Cmax: 9.6 uM
      Area Under the Curve:: 6.5 μM·h
      Volume of Distribution at Steady-State: 3.7 L/kg
      Target engagement assay: Danusertib was seen to be efficacious in a range of tumor models. The dose-dependent growth inhibition induced in the HL-60 xenograft model. Tested at doses between 7.5 mg/kg and 30 mg/kg given iv bid for 5 days, the compound showed good dose-dependency and a tumor growth inhibition of up to 98%. At the highest dose (30 mg/Kg) there was evidence of tumor regression and, in two cases out of eight, cures.

      DOI Reference: 10.1021/jm060897w

      Orthogonal Probes def

      AMG-900
      XMD-12

      Chemical Information

      Molecular Formula C26H30N6O3
      SMILEs CO[C@@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1
      InChI InChI=1S/C26H30N6O3/c1-30-12-14-31(15-13-30)20-10-8-19(9-11-20)25(33)27-24-21-16-32(17-22(21)28-29-24)26(34)23(35-2)18-6-4-3-5-7-18/h3-11,23H,12-17H2,1-2H3,(H2,27,28,29,33)/t23-/m1/s1
      Molecular weight 474.24 Da
      AlogP 0.0
      HBond acceptors 9
      HBond donors 2
      Atoms 65

      References

      Publications

      Cross References

      canSARChEMBLBindingDBBindingDB

      Vendors

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      Expert Reviews

      No SERP comments found for Danusertib

      Probe Danusertib is in the process of SERP review.

      Please continue to check back for new reviews and commentary.