Chemical Probes logo
DANAVOREXTON | DANAVOREXTON : Agonist of HCRTR2
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

More...

Targets Biochemical/Biophysical Potency Cellular Potency
HCRTR2
  • Kd:48 nM
  • EC50:5.5 nM
  • EC50:15 nM
Agonist
300 nM - 1µM
100 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Within target family - T-516 (TAK-925 analog) had a > 6000-fold OX2R selectivity against OX1R in cal ...

Potency
Cellular
In Vitro

HCRTR2

Mode of Action: Agonist

Structure-Activity-Relationship data available? No

DOI Reference: 10.1016/j.pbb.2019.172794

In Vivo Validations

Mouse
Dose: 3 mg/Kg
Route of delivery: Subcutaneous
Organ of interest (O): Brain

DOI Reference: 10.1016/j.pbb.2019.172794

Orthogonal Probes def

CANSAR1744939

Chemical Information

Molecular Formula C21H32N2O5S
SMILEs COC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@@H](c2ccccc2)CC1
InChI InChI=1S/C21H32N2O5S/c1-27-21(24)23-14-6-9-19(22-29(2,25)26)20(23)15-28-18-12-10-17(11-13-18)16-7-4-3-5-8-16/h3-5,7-8,17-20,22H,6,9-15H2,1-2H3/t17-,18+,19-,20-/m0/s1
Molecular weight 424.20 Da
AlogP 2.878000000000001
HBond acceptors 7
HBond donors 1
Atoms 61

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the portal.

Expert Reviews

by SERP
(on 19 Apr 2022)
Cellular Use Rating
In Model Organisms
Sufficient brain concentrations are achieved in the mouse, however, the authors note that a short plasma half-life is observed.
by SERP
(on 8 Jul 2022)
In Model Organisms
(The reviewer did not leave any public comments)
by SERP+
(on 14 Oct 2025)
Cellular Use Rating
In Model Organisms
This is a highly potent and selective full agonist of human OX2R, with a range of functional characterisation. However, no cytotoxicity data reported, so the upper limit for suitable concentration is not...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria