CVN417 |
CVN417 : Antagonist of CHRNA6
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| CHRNA6 |
|
Antagonist
up to 1 uM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
Selective against subunit Alpha3 and Alpha4. IC50 2560 nM and 657 nM respectively.
Outside Target Fa ...
Potency Cellular
In Vitro
CHRNA6
Mode of Action: Antagonist
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/acs.jmedchem.3c00630
In Vivo Validations
Rat
Dose: 0.5 mg/Kg
Route of delivery:
Intravenous
Systemic clearance:
38.2 mL/min/Kg
Area Under the Curve::
205 ng·h/mL
Volume of Distribution at Steady-State:
12.3 L/Kg
DOI Reference: 10.1021/acs.jmedchem.3c00630
Dose: 10 mg/Kg
Route of delivery:
Oral
Plasma half life:
5.9 h
Cmax:
0.35 uM
Area Under the Curve::
775 ng·h/mL
Bioavailability:
11%
DOI Reference: 10.1021/acs.jmedchem.3c00630
Dog
Dose: 1 mg/Kg
Route of delivery:
Intravenous
Systemic clearance:
91 mL/min/Kg
Area Under the Curve::
13.5 ng·h/mL
Volume of Distribution at Steady-State:
11.4 L/Kg
DOI Reference: 10.1021/acs.jmedchem.3c00630
Dose: 3 mg/Kg
Route of delivery:
Oral
Plasma half life:
7.8 h
Bioavailability:
43.8%
DOI Reference: 10.1021/acs.jmedchem.3c00630
Chemical Information
| Molecular Formula | C18H23ClN4O2 |
| SMILEs | COc1ccc(-c2cc(C(=O)N[C@H]3CCCN(C)C3)nn2C)c(Cl)c1 |
| InChI | InChI=1S/C18H23ClN4O2/c1-22-8-4-5-12(11-22)20-18(24)16-10-17(23(2)21-16)14-7-6-13(25-3)9-15(14)19/h6-7,9-10,12H,4-5,8,11H2,1-3H3,(H,20,24)/t12-/m0/s1 |
| Molecular weight | 362.15 Da |
| AlogP | 0.0 |
| HBond acceptors | 6 |
| HBond donors | 1 |
| Atoms | 48 |
Vendors
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