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CST967 | CST967 : Degrader (PROTAC) of USP7
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
USP7
  • IC50:1600 nM
  • DC50:17 nM
Degrader (PROTAC)
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
A global-proteome analysis of the downstream effects of the USP7 PROTAC was assessed using diaPASEF- ...

Potency
Cellular
In Vitro

USP7

Mode of Action: Degrader (PROTAC)

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1039/D2CC02094G

Chemical Information

Molecular Formula C51H58N8O9
SMILEs C[C@H](CC(=O)N1CCC(O)(Cn2cnc3cc(NC(=O)CCC4CCN(C(=O)C5CCN(c6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)ccc3c2=O)CC1)c1ccccc1
InChI InChI=1S/C51H58N8O9/c1-32(34-5-3-2-4-6-34)27-45(62)56-25-19-51(68,20-26-56)30-58-31-52-41-28-36(8-10-39(41)48(58)65)53-43(60)13-7-33-15-21-57(22-16-33)47(64)35-17-23-55(24-18-35)37-9-11-38-40(29-37)50(67)59(49(38)66)42-12-14-44(61)54-46(42)63/h2-6,8-11,28-29,31-33,35,42,68H,7,12-27,30H2,1H3,(H,53,60)(H,54,61,63)/t32-,42?/m1/s1
Molecular weight 926.43 Da
AlogP 4.218900000000003
HBond acceptors 17
HBond donors 3
Atoms 126

Expert Reviews

by SERP
(on 8 Jul 2023 )
Cellular Use Rating
CST967 is currently (July 2023), alongside with with U7D-1, the best available PROTAC tool compounds targeting USP7 for degradation. It has been demonstrated that CST967 can induce (as Dmax) 85 % reduction...
by SERP+
(on 20 Feb 2025 )
Cellular Use Rating
The compound is well characterized and appears as a potent target for USP7 degradation. However, some deeper evidence of target engagement is needed.
by SERP+
(on 6 Feb 2026 )
Cellular Use Rating
CST967 is a CRBN based USP7 degrader. The probe shows dose dependent degradation of USP7 with a Dmax of 85% at 1 uM and a DC50 of 17 nm over 24 h. Several controls were carried out with pretreatment...
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