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CQ627 | CQ627 : Molecular Glue of RIOK2
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
RIOK2
  • IC50:98 nM
  • DC50:410 nM
  • IC50:<350 nM
  • Activity:1 µM
Molecular Glues
up to 1 uM

Selectivity

Potency
Cellular
In Vitro

RIOK2

Mode of Action: Molecular Glues

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1016/j.ejmech.2024.117166

In Vivo Validations

Rat
Dose: 5 mg/Kg
Route of delivery: Intravenous
Plasma half life: 0.6 ± 0.1 h
Systemic clearance: 4154.4 ± 542.3 mL/h/Kg
Cmax: 1437 ± 356 ng/mL
Area Under the Curve:: 1209 ± 146 ng/mL*h

DOI Reference: 10.1016/j.ejmech.2024.117166

Dose: 10 mg/Kg
Route of delivery: Intraperitoneal
Plasma half life: 8.1 ± 1.3 h
Cmax: 90.6 ± 14.0 ng/mL
Area Under the Curve:: 1200 ± 222 ng/mL*h
Bioavailability: 49.7 ± 9.2 %

DOI Reference: 10.1016/j.ejmech.2024.117166

Chemical Information

Molecular Formula C36H27F4N7O4
SMILEs COc1ccc(-c2ccc3[nH]c(=O)c4nnn(-c5ccc(N6CCN(C(=O)/C=C/C(=O)c7ccc(F)cc7)CC6)c(C(F)(F)F)c5)c4c3c2)cn1
InChI InChI=1S/C36H27F4N7O4/c1-51-31-12-5-23(20-41-31)22-4-9-28-26(18-22)34-33(35(50)42-28)43-44-47(34)25-8-10-29(27(19-25)36(38,39)40)45-14-16-46(17-15-45)32(49)13-11-30(48)21-2-6-24(37)7-3-21/h2-13,18-20H,14-17H2,1H3,(H,42,50)/b13-11+
Molecular weight 697.21 Da
AlogP 5.578200000000005
HBond acceptors 11
HBond donors 1
Atoms 78
PAINS * Yes

* This is an automated alert only, and may not necessarily indicate an issue with this probe. ( Learn more about PAINS )

References

Publications

Cross References

Expert Reviews

by SERP
(on 20 Mar 2025 )
Cellular Use Rating
In Model Organisms
CQ627 has a number of limitations for its use as a probe: 1. It has been reported to have a DC50 of 410 nM, which is at least one order of magnitude higher than ideal for its use as a probe. 2. Also,...
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