CPS2 |
CPS2 : Degrader (PROTAC) of CDK2
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| CDK2 |
|
|
Degrader (PROTAC)
250 nM
up to 1 uM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
Kinome scan for 1 μM CPS2 highlighted unwanted interactions with AURKA and KDR.
Cell-free binding- ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
Proteomics analysis was performed in NB4 cells treated with 250-nM CPS2 for 6 h confirming CDK2 was ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
Selectivity within target family:
CPS2 induced only CDK2 degradation and did not directly perturb th ...
Selectivity Assessment Description:
Western blot
Potency Cellular
In Vitro
CDK2
Mode of Action: Degrader (PROTAC)
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1038/s41589-021-00742-5
Negative Control Compounds
Chemical Information
| Molecular Formula | C38H42N12O10S2 |
| SMILEs | Cc1ccsc1C(=O)n1nc(Nc2ccc(S(=O)(=O)NCCOCc3cn(CCOCCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)nn3)cc2)nc1N |
| InChI | InChI=1S/C38H42N12O10S2/c1-23-11-20-61-32(23)36(55)50-37(39)44-38(46-50)42-24-5-7-26(8-6-24)62(56,57)41-13-16-60-22-25-21-48(47-45-25)14-17-59-19-18-58-15-12-40-28-4-2-3-27-31(28)35(54)49(34(27)53)29-9-10-30(51)43-33(29)52/h2-8,11,20-21,29,40-41H,9-10,12-19,22H2,1H3,(H,43,51,52)(H3,39,42,44,46) |
| Molecular weight | 890.26 Da |
| AlogP | 0.0 |
| HBond acceptors | 22 |
| HBond donors | 6 |
| Atoms | 104 |