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CMLD-2 | Inhibitor of ELAVL1
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
ELAVL1
  • Ki:0.35 uM
Inhibitor
20 uM

Selectivity

Potency
Cellular
In Vitro

ELAVL1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

Negative Control Compounds

NC-3

Chemical Information

Molecular Formula C31H31NO6
SMILEs COc1ccc(C(CC(=O)N2CCCC2)c2c(OC)cc(OC)c3c(-c4ccccc4)cc(=O)oc23)cc1
InChI InChI=1S/C31H31NO6/c1-35-22-13-11-21(12-14-22)23(17-27(33)32-15-7-8-16-32)29-25(36-2)19-26(37-3)30-24(18-28(34)38-31(29)30)20-9-5-4-6-10-20/h4-6,9-14,18-19,23H,7-8,15-17H2,1-3H3
Molecular weight 513.22 Da
AlogP 5.6302
HBond acceptors 7
HBond donors --
Atoms 69

References

Publications

    Cross References

    canSARChEMBLBindingDB

    Vendors

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    Expert Reviews

    by SERP
    (on 26 Jul 2020 )
    Cellular Use Rating
    CMLD-2 is a compound that emerged from a limited size HTS conducted to identify disruptors of binding between HuR protein (also known as ELAVL1) and mRNA adenine- and uridine-rich elements (ARE). The...
    by SERP
    (on 28 Aug 2020 )
    Cellular Use Rating
    The molecule is chiral and lacks an enantiomeric comparison. Care using this probe must be taken as chromone template is known to interfere with spectrometric assays. The compound is reported as active...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria