CLM296 |
CLM296 : Inhibitor of ALDH1A3
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| ALDH1A3 |
|
Inhibitor
up to 100 nM
Selectivity
In Cell Selectivity Assessment
Potency Assay Off-Target:
CLM296 had no effect on ALDH1A1-mediated Aldefluor fluorescence even at 100 μM in cell
Potency Cellular
In Vitro
ALDH1A3
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? No
DOI Reference: 10.1016/j.isci.2026.114863
In Vivo Validations
Mouse
Dose: 4 mg/Kg
Route of delivery:
Intraperitoneal
Plasma half life:
8.62 h
Systemic clearance:
39.8 mL/h/Kg
Cmax:
24.24 uM
Tmax:
1 h
Area Under the Curve::
233.4 uM*h/L
Volume of Distribution at Steady-State:
494.4 mL/Kg
DOI Reference: 10.1016/j.isci.2026.114863
Dose: 4 mg/Kg
Route of delivery:
Oral
Plasma half life:
12.9 h
Systemic clearance:
72.2 mL/h/Kg
Cmax:
10.97 uM
Tmax:
4 h
Area Under the Curve::
128.5 uM*h/L
Volume of Distribution at Steady-State:
1.35 L/Kg
DOI Reference: 10.1016/j.isci.2026.114863
Chemical Information
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