CK156 |
CK156 : Inhibitor of STK17A
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| STK17A |
|
|
Inhibitor
up to 5 uM
Selectivity
In Vitro Selectivity Assessment
Selectivity Assessment Description:
The selectivity profile of CK156 was determined with the scanMAX® assay from DiscoverX at 1000 and 1 ...
Potency Cellular
In Vitro
STK17A
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/acs.jmedchem.2c00173
Negative Control Compounds
CANSAR3550543
Notes: The negative control CKJB71 showed no activity in a DSF assay for 90 kinases and no on-target activity determined by NanoBRET in intact cells and in lysed cells.
Chemical Information
| Molecular Formula | C21H25N5O3 |
| SMILEs | CC(C)(C)NC(=O)c1ccc2cc1OCCOCCNc1ccn3ncc-2c3n1 |
| InChI | InChI=1S/C21H25N5O3/c1-21(2,3)25-20(27)15-5-4-14-12-17(15)29-11-10-28-9-7-22-18-6-8-26-19(24-18)16(14)13-23-26/h4-6,8,12-13H,7,9-11H2,1-3H3,(H,22,24)(H,25,27) |
| Molecular weight | 395.20 Da |
| AlogP | 0.0 |
| HBond acceptors | 8 |
| HBond donors | 2 |
| Atoms | 54 |