CG211 |
CG211 : Inhibitor of RIOK2
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| RIOK2 |
|
|
Inhibitor
up to 5 µM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
KINOMEscan approach was used to test the specificity of the binding of compound CQ211 to RIOK2 by sc ...
Potency Cellular
In Vitro
RIOK2
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/acs.jmedchem.2c00271
In Vivo Validations
Rat
Dose:
Route of delivery:
Intravenous
Plasma half life:
16.1 ± 1.9 h
Cmax:
586.8 ± 26.0 ng/mL
Tmax:
0.08 ± 0.00 h
Area Under the Curve::
778.4 ± 29.8 h*ng/mL
DOI Reference: 10.1021/acs.jmedchem.2c00271
Dose:
Route of delivery:
Oral
Plasma half life:
15.5 ± 10.8 h
Cmax:
13.1 ± 4.5 ng/mL
Tmax:
0.83 ± 1.01 h
Area Under the Curve::
119.1 ± 17.0 h*ng/mL
Bioavailability:
3.1 ± 0.4%
DOI Reference: 10.1021/acs.jmedchem.2c00271
Chemical Information
| Molecular Formula | C26H22F3N7O2 |
| InChI | InChI=1S/C26H22F3N7O2/c1-38-22-7-3-16(14-31-22)15-2-5-20-18(12-15)24-23(25(37)32-20)33-34-36(24)17-4-6-21(19(13-17)26(27,28)29)35-10-8-30-9-11-35/h2-7,12-14,30H,8-11H2,1H3,(H,32,37) |
| Molecular weight | 521.18 Da |
| AlogP | 0.0 |
| HBond acceptors | 9 |
| HBond donors | 2 |
| Atoms | 60 |
| PAINS * | Yes |
* This is an automated alert only, and may not necessarily indicate an issue with this probe. ( Learn more about PAINS )