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Ceritinib | Ceritinib : Inhibitor of ALK
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
ALK
  • IC50:0.2 nM
  • IC50:26 nM
  • IC50:22.8 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment

Potency: IC50 - FLT3 60 nM, FGFR2 260 nM, RET 400 nM, FGFR3 430 nM

Potency Assay Off-Target:
Enzymatic Inhibition assay (LabChip mobility-shift assay)
Selectivity Assessment Description:
Enzymatic Kinase Profile in uM: ABL 1.25, FGFR4 0.95, LYN 0.84, AKT >10, FLT3 0.06, cMET 3.17, ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
Cell Proliferation Assay (Bright-Glo luciferase assay)
Selectivity Assessment Description:
Cellular Kinase Profile in Ba/F3 Cells (IC50, uM): Tel-ALK 40.7 ± 5.3, Tel-JAK2, 2160 ± 320, Tel- ...

Potency
Cellular
In Vitro

ALK

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/jm400402q

In Vivo Validations

Mouse (M), Rat (R), Dog (D), Monkey (C)
Dose: 5 IV, 20 PO (M); 3 IV, 10 PO (R); 5 IV, 20 PO (D); 5 IV, 60 PO (C) mg/Kg
Route of delivery: Intravenous, Oral
Plasma half life: 6.2 (M), 9.1 (R), 21 (D), 26 (M) h (IV)
Systemic clearance: 26.6 (M), 36.8 (R), 9.2 (D), 12.8 (C) mL/min/Kg IV
Area Under the Curve:: 5634 IV, 12296 PO (M); 2779 IV, 6092 PO (R); 18096 IV, 67904 PO (D); 11305 IV, 76325 PO (C) h*nM
Bioavailability: 55 (M), 66 (R), 119 (D), 56(C) % PO
Volume of Distribution at Steady-State: 9.7 (M), 21.2 (R), 13.5 (D), 15 (C) L/Kg IV

DOI Reference: 10.1021/jm400402q

Orthogonal Probes def

CH5424802
TL13-112
Brigatinib

Chemical Information

Molecular Formula C28H36ClN5O3S
SMILEs Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1
InChI InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)
Molecular weight 557.22 Da
AlogP 6.36192
HBond acceptors 8
HBond donors 3
Atoms 74

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Expert Reviews

No SERP comments found for Ceritinib

Probe Ceritinib is in the process of SERP review.

Please continue to check back for new reviews and commentary.