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CDD-1653 | CDD-1653 : Inhibitor of BMPR2
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
BMPR2
  • IC50:2.8 nM
  • IC50:6920 nM
  • Activity:25 µM
Inhibitor
up to 25 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
KinomeSCAN @ 1 uM against 403 kinases with closest off-target ALK1 >1000 nM

Potency
Cellular
In Vitro

BMPR2

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.2c01886

Chemical Information

Molecular Formula C21H22N6O4S
SMILEs COc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CCN(c2ccccc2)C(=O)C1
InChI InChI=1S/C21H22N6O4S/c1-31-18-13-23-21(24-15-6-5-9-17(12-15)32(22,29)30)25-20(18)26-10-11-27(19(28)14-26)16-7-3-2-4-8-16/h2-9,12-13H,10-11,14H2,1H3,(H2,22,29,30)(H,23,24,25)
Molecular weight 454.14 Da
AlogP 0.0
HBond acceptors 10
HBond donors 3
Atoms 54

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Expert Reviews

No SERP comments found for CDD-1653

Probe CDD-1653 is in the process of SERP review.

Please continue to check back for new reviews and commentary.