CCT374705 |
CCT374705 : Inhibitor of BCL6
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| BCL6 |
|
|
Inhibitor
up to 1 µM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
Safety profiling of CCT374705 was carried out, and all targets (78) showed a Kd above 1 μM, although ...
Potency Cellular
In Vitro
BCL6
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? No
DOI Reference: 10.1021/acs.jmedchem.3c00155
In Vivo Validations
Mouse
Dose: 1 mg/Kg IV, 5 mg/Kg PO
Route of delivery:
Intravenous, Oral
Plasma half life:
2.94 h IV
Systemic clearance:
1.6 mL/min/Kg IV
Cmax:
8652 nM PO
Area Under the Curve::
42883 nM*h PO
Fb :
99.283%
Bioavailability:
48% PO
Volume of Distribution at Steady-State:
0.39 L IV
DOI Reference: 10.1021/acs.jmedchem.3c00155
Chemical Information
| Molecular Formula | C21H18ClF3N4O2 |
| SMILEs | Cn1c(=O)c2c(c3cc(Nc4ccnc(F)c4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 |
| InChI | InChI=1S/C21H18ClF3N4O2/c1-29-14-5-4-11(27-13-6-7-26-19(23)15(13)22)8-12(14)16-17(20(29)30)31-9-21(24,25)18(28-16)10-2-3-10/h4-8,10,18,28H,2-3,9H2,1H3,(H,26,27)/t18-/m0/s1 |
| Molecular weight | 450.11 Da |
| AlogP | 0.0 |
| HBond acceptors | 6 |
| HBond donors | 2 |
| Atoms | 49 |
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