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CCT241533 | CCT241533 : ATP competitive inhibitor of CHEK2
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CHEK2
  • Ki:1.16 nM
ATP competitive
500 nM - 5 uM

Selectivity

In Vitro Selectivity Assessment

Potency: IC50 - CHEK1 245 nM

Potency Assay Off-Target:
In a radiometric binding assay, 1 uM CCT241533 inhibited >80% of AHK, MARK3, GCK and MLK1 activity.

Potency
Cellular
In Vitro

CHEK2

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? No

In Vivo Validations

mouse
Dose:

Reference: --

Chemical Information

Molecular Formula C23H27FN4O4
SMILEs COc1cc2nc(-c3cc(F)ccc3O)nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC
InChI InChI=1S/C23H27FN4O4/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29/h5-9,15,17,25,29-30H,10-11H2,1-4H3,(H,26,27,28)/t15-,17-/m1/s1
Molecular weight 442.20 Da
AlogP 0.0
HBond acceptors 8
HBond donors 4
Atoms 59

References

Publications

    Cross References

    canSARChEMBLBindingDBPDB

    Vendors

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    Expert Reviews

    by SERP
    (on 19 Jun 2016 )
    Cellular Use Rating
    CCT241533 is a potent (biochemical IC50 3 nM) and selective (63-fold vs CHK1, >90% inhibition of 3 out of 85 kinases tested at 1 uM) inhibitor of CHK2. Mechanistic inhibition of CHK2 in cancer cells...
    by SERP
    (on 19 Jun 2016 )
    Cellular Use Rating
    This probe has a very good selectivity profile; activity was found for only four kinases (PHK, GCK, MLKI, and MARK3) out of a panel of 85. The X-ray structure shows CCT241533 bound to CHK2 in the kinase...
    by SERP
    (on 22 May 2017 )
    Cellular Use Rating
    In Model Organisms
    CCT241533 is a selective, ATP-competitive CHEK2 inhibitor with biochemical (3 nM) and cellular activity. The compound also inhibits CHEK1 in vitro at 190-245 nM and potentiated the anti-proliferative...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria