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BYL-719 | BYL-719 : ATP competitive inhibitor of PIK3CA
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
PIK3CA
  • IC50:5 nM
  • IC50:74 nM
ATP competitive
10 nM - 1 uM

Selectivity

In Vitro Selectivity Assessment

Potency: IC50 - PIK3CB 1200 nM, PIK3CD 290 nM, PIK3CG 250 nM

Potency Assay Off-Target:
In vitro kinase assay. BYL-719 was >50-fold selective of PIK3CA over 442 kinases in vitro (Ambit). ...
Selectivity Assessment Description:
IC50 for CYP450A > 10 uM
In Cell Selectivity Assessment

Potency: IC50 - PI3KCB 2200 nM, PI3KCD 1200 nM

Potency
Cellular
In Vitro

PIK3CA

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? Yes

PMID Reference: 23726034

In Vivo Validations

Rat
Dose: 1 mg/kg
Route of delivery: Intravenous
Plasma half life: 2. 9 hr
Systemic clearance: 10 mL/min/kg

PMID Reference: 23726034

Orthogonal Probes def

Pictilisib

Chemical Information

Molecular Formula C19H22F3N5O2S
SMILEs Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(C(C)(C)C(F)(F)F)c1
InChI InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1
Molecular weight 441.14 Da
AlogP 3.835020000000002
HBond acceptors 7
HBond donors 3
Atoms 52

References

Publications

Cross References

canSARChEMBLBindingDBPDB

Vendors

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Expert Reviews

by SERP
(on 10 Jun 2016 )
Cellular Use Rating
In Model Organisms
( The reviewer did not leave any comments )
by SERP
(on 18 Jun 2016 )
Cellular Use Rating
In Model Organisms
Chemical Neighbourhood for QSAR: 15 molecules similar (>0.80) to BYL-719 with in vitro affinities for PIK3CA were found in public repositories (e.g., ChEMBL).
by SERP
(on 5 Jul 2017 )
Cellular Use Rating
In Model Organisms
( The reviewer did not leave any comments )
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