Chemical Probes logo
BTZO-1 | ARE Activator of MIF
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MIF
  • Kd:68.6 nM
  • Kd:147 nM
  • MEC1.5, MEC2.0:MEC1.5 16 nM
ARE Activator
up to 1 uM

Selectivity

Potency
Cellular
In Vitro

MIF

Mode of Action: ARE Activator

Structure-Activity-Relationship data available? No

DOI Reference: 10.1016/j.chembiol.2010.10.011

Negative Control Compounds

BTZO-3
BTZO-4

Chemical Information

Molecular Formula C13H8N2OS
SMILEs O=c1nc(-c2ccccn2)sc2ccccc12
InChI InChI=1S/C13H8N2OS/c16-12-9-5-1-2-7-11(9)17-13(15-12)10-6-3-4-8-14-10/h1-8H
Molecular weight 240.04 Da
AlogP 2.7185000000000006
HBond acceptors 3
HBond donors --
Atoms 25

References

Publications

Cross References

SGC additional analysis

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the portal.

Expert Reviews

by SERP
(on 24 Sept 2020 )
Cellular Use Rating
( The reviewer did not leave any comments )
by SERP
(on 18 Oct 2020 )
Cellular Use Rating
In Model Organisms
This compound was discovered using a cellular assay in rat cardiomyocytes and characterized in rat H9c2 cells, so it is appropriate as a cellular probe in this context. Binding studies were done with...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria