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BO-264 | BO-264 : Inhibitor of TACC3
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
TACC3
  • Kd:1.5 nM
  • IC50:190 nM
  • IC50:130 nM
  • Activity:1 μmol/L
Inhibitor
1 µM

Selectivity

In Cell Selectivity Assessment
Selectivity Assessment Description:
Dose-response screen of the antiproliferative capacity of BO-264 in the NCI-60 human cancer cell lin ...

Potency
Cellular
In Vitro

TACC3

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1158/1535-7163.MCT-19-0957

In Vivo Validations

Mouse
Dose: 25 mg/Kg
Route of delivery: Oral

DOI Reference: 10.1158/1535-7163.MCT-19-0957

Orthogonal Probes def

CANSAR3445349
CANSAR3445208

Chemical Information

Molecular Formula C18H19N5O3
SMILEs COc1ccc(-c2cc(/N=c3\ccnc(N4CCOCC4)[nH]3)on2)cc1
InChI InChI=1S/C18H19N5O3/c1-24-14-4-2-13(3-5-14)15-12-17(26-22-15)20-16-6-7-19-18(21-16)23-8-10-25-11-9-23/h2-7,12H,8-11H2,1H3,(H,19,20,21)
Molecular weight 353.15 Da
AlogP 0.0
HBond acceptors 8
HBond donors 1
Atoms 45

References

Publications

Cross References

canSARPubMed

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Expert Reviews

No SERP comments found for BO-264

Probe BO-264 is in the process of SERP review.

Please continue to check back for new reviews and commentary.