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BIIB021 | Inhibitor of HSP90AA1, HSP90AB1
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
HSP90AA1
  • Ki:1.7 ± 0.4 nM
  • EC50, IC50:38 ± 10 nM (EC50); 60-310 nM (IC50)
HSP90AB1
  • Ki:1.7 ± 0.4 nM
  • EC50, IC50:38 ± 10 nM (EC50)
Inhibitor
400-1000 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Tested for selectivity against protein kinases and ATPases, with no significant inhibition detect ...

Potency
Cellular
In Vitro

HSP90AA1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

HSP90AB1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

In Vivo Validations

Mouse
Dose: 31, 62.5, 125 mg/Kg, 75, 150 mg/Kg, 100 mg/Kg
Route of delivery: Oral
Plasma half life: 0.5 (@ 75 mg/Kg), 1 (@ 150 mg/Kg) h, 0.8h (@ 100 mg/Kg)
Cmax: 10.2 (@ 75 mg/Kg) and 19.5 ug/ml (@ 150 mg/Kg)
Area Under the Curve:: 2.3 (@ 75 mg/Kg) and 9.1 ug/mL (@ 150 mg/Kg)

DOI Reference: 10.1158/1535-7163.MCT-08-0758

Orthogonal Probes def

Onalespib
Luminespib

Chemical Information

Molecular Formula C14H15ClN6O
SMILEs COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc32)c1C
InChI InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20)
Molecular weight 318.10 Da
AlogP 2.1306399999999996
HBond acceptors 7
HBond donors 2
Atoms 37

References

Publications

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Expert Reviews

by SERP
(on 9 Dec 2021 )
Cellular Use Rating
In Model Organisms
( The reviewer did not leave any comments )
by SERP
(on 27 Mar 2022 )
Cellular Use Rating
In Model Organisms
BII021 is a N-terminal HSP90 inhibitor and its worth to note that C-terminal HSP90 inhibitors also reported.
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