BIBR-1532 |
BIBR-1532 : Allosteric of TERT
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| TERT |
|
|
Allosteric
higher concentrations up to 50 µM may be required
up to 10 uM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
The selectivity profile for BIBR1532 was assessed in a panel of DNA and RNA polymerases. Enzymatic a ...
Potency Cellular
In Vitro
TERT
Mode of Action: Allosteric
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1038/s41589-026-02238-6
In Vivo Validations
Mouse
Dose: 1 mg/Kg
Route of delivery:
Intravenous
Volume of Distribution at Steady-State:
0.1 L/Kg
Target engagement assay:
LD50 of 2000 mg/kg
DOI Reference: 10.1038/s41589-026-02238-6
Dose: 5 mg/Kg
Route of delivery:
Oral
Plasma half life:
12.7 h
Area Under the Curve::
140,761 ng*h/mL
Bioavailability:
80%
DOI Reference: 10.1038/s41589-026-02238-6
Negative Control Compounds
BIBR1654
Notes: The structurally related molecule BIBR1654 serves as a negative control with IC50 (hTERT) = 5 µM.
Chemical Information
| Molecular Formula | C21H17NO3 |
| SMILEs | C/C(=C\C(=O)Nc1ccccc1C(=O)O)c1ccc2ccccc2c1 |
| InChI | InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+ |
| Molecular weight | 331.12 Da |
| AlogP | 4.580000000000003 |
| HBond acceptors | 4 |
| HBond donors | 2 |
| Atoms | 42 |