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BIBO3304 | BIBO3304 : Antagonist of NPY1R
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NPY1R
    • IC50:0.38 nM
    • IC50:0. 69 nM
    Antagonist
    100 nM
    up to 1 uM

    Selectivity

    In Vitro Selectivity Assessment
    Potency Assay Off-Target:
    Selectivity within target family: BIBO3304 binds with more than 1,000-10,000-fold lower affinity to ...

    Potency
    Cellular
    In Vitro

    NPY1R

    Mode of Action: Antagonist

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1038/sj.bjp.0702084

    In Vivo Validations

    Rat
    Dose: 30 µg
    Route of delivery: Cannulae inserted into the PVN (paraventricular nucleus)
    Target engagement assay: Inhibition of NPY-induced feeding by BIBO 3304, but lack of effect of the inactive enantiomer BIBO 3457 to inhibit NPY-induced feeding

    DOI Reference: 10.1038/sj.bjp.0702084

    Negative Control Compounds

    BIBO3457
    Notes: (S)-enantiomer displays low affinity towards both the human and the rat Y1 receptor.
    SMILES: https://capture.dropbox.com/aMUFQ3I6BZHXb70D

    Chemical Information

    Molecular Formula C29H35N7O3
    SMILEs N=C(N)NCCC[C@@H](/N=C(\O)C(c1ccccc1)c1ccccc1)/C(O)=N/Cc1ccc(CNC(=N)O)cc1
    InChI InChI=1S/C29H35N7O3/c30-28(31)33-17-7-12-24(26(37)34-18-20-13-15-21(16-14-20)19-35-29(32)39)36-27(38)25(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-6,8-11,13-16,24-25H,7,12,17-19H2,(H,34,37)(H,36,38)(H4,30,31,33)(H3,32,35,39)/t24-/m1/s1
    Molecular weight 529.28 Da
    AlogP 0.0
    HBond acceptors 10
    HBond donors 9
    Atoms 74

    Vendors

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    Expert Reviews

    by SERP
    (on 29 Dec 2022)
    Cellular Use Rating
    In Model Organisms
    (The reviewer did not leave any public comments)
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