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BI-9508 | BI-9508 : Agonist of GPR88
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
GPR88
    • EC50:47 nM
    Agonist
    up to 1 uM

    Selectivity

    In Vitro Selectivity Assessment
    Potency Assay Off-Target:
    Assessed in the CEREP SafetyScreen44 at 10 uM showing acceptable selectivity

    Potency
    Cellular
    In Vitro

    GPR88

    Mode of Action: Agonist

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1021/acs.jmedchem.4c00665

    In Vivo Validations

    Mouse
    Dose: 1 umol/Kg IV, 10 umol/Kg PO, 2 umol/Kg IP
    Route of delivery: Intravenous, Oral, Intraperitoneal
    Plasma half life: MRT 2.89 h
    Systemic clearance: 34.63% QH
    Cmax: 388.33 nM
    Tmax: 0.19 h
    Bioavailability: 10%
    Volume of Distribution at Steady-State: 5.44 L/Kg

    DOI Reference: 10.1021/acs.jmedchem.4c00665

    Negative Control Compounds

    canSAR7378125
    Notes: BI-0823 (cpd 7) is inactive in hGPR88 Gi1 BRET assay

    Chemical Information

    Molecular Formula C28H29F2N5O3
    SMILEs CC(C)Oc1ccc(-c2ccc(N(CCOC(F)F)C(=O)[C@@H]3C[C@H]3c3ccncn3)c3c2cnn3C)cc1
    InChI InChI=1S/C28H29F2N5O3/c1-17(2)38-19-6-4-18(5-7-19)20-8-9-25(26-23(20)15-33-34(26)3)35(12-13-37-28(29)30)27(36)22-14-21(22)24-10-11-31-16-32-24/h4-11,15-17,21-22,28H,12-14H2,1-3H3/t21-,22-/m1/s1
    Molecular weight 521.22 Da
    AlogP 5.193400000000004
    HBond acceptors 8
    HBond donors --
    Atoms 67

    Expert Reviews

    by SERP
    (on 31 Oct 2024 )
    Cellular Use Rating
    In Model Organisms
    BI-9508, a compound developed through medicinal chemistry modification based on existing scaffold, has proven to be a promising active compound, demonstrating significant progress in both in vitro and...
    by SERP
    (on 19 Nov 2024 )
    Cellular Use Rating
    In Model Organisms
    BI-9508 appears to be the best available tool compound as a GPR88 agonist (i.e. GPR88 agonistic chemical probe), making it valuable for in vitro studies and structural biology experiments. This compound...
    by SERP
    (on 12 Dec 2024 )
    Cellular Use Rating
    In Model Organisms
    ( The reviewer did not leave any comments )
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