BI-1942 |
BI-1942 : Inhibitor of CMA1
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| CMA1 |
|
|
Inhibitor
100 nM
Selectivity
In Vitro Selectivity Assessment
Selectivity Assessment Description:
Selectivity within target family: Eurofins protease panel (35 at 10 µM): Only off-target is CTSG (ca ...
Potency Cellular
In Vitro
CMA1
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? No
DOI Reference: 10.1021/jm400138z
Chemical Information
| Molecular Formula | C24H26N4O4 |
| SMILEs | CC[C@H](CC(=O)O)n1c(=O)c2ncccc2n(Cc2cn(C)c3cc(C)cc(C)c23)c1=O |
| InChI | InChI=1S/C24H26N4O4/c1-5-17(11-20(29)30)28-23(31)22-18(7-6-8-25-22)27(24(28)32)13-16-12-26(4)19-10-14(2)9-15(3)21(16)19/h6-10,12,17H,5,11,13H2,1-4H3,(H,29,30)/t17-/m1/s1 |
| Molecular weight | 434.20 Da |
| AlogP | 0.0 |
| HBond acceptors | 8 |
| HBond donors | 1 |
| Atoms | 58 |