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BI-1935 | Inhibitor of EPHX2
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
EPHX2
  • IC50:7 nM
  • IC50:< 1 nM
Inhibitor
10 nM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Internal screen against hCYP epoxygenases 2J2/2C9/2C19 and IL-2: > 100-fold selectivity achieved (> ...
In Cell Selectivity Assessment
Selectivity Assessment Description:
Off Target Screen - Panlabs panel: 61/67 < 20% Inhibition @ 10 μM, 5/67 < 80% Inhibition @ 10 μM, Th ...

Potency
Cellular
In Vitro

EPHX2

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

Other Reference: Peer Reviewed at SGC

In Vivo Validations

Rat
Dose: 1.2 mg/Kg IV, 3 mg/Kg PO
Route of delivery: Intravenous, Oral
Systemic clearance: 2.9 ml/min/kg IV
Cmax: 3.6 uM PO
Tmax: 2.7 h PO
Area Under the Curve:: 30582 nM*h PO, 14463 nM*h IV
Bioavailability: 85% PO
Volume of Distribution at Steady-State: 0.5 L/Kg IV

Other Reference: Peer Reviewed at SGC

Negative Control Compounds

BI 2049
Notes: BI-2049 can be used as in vitro negative control (IC50 h-sEH > 3 µM)

Chemical Information

Molecular Formula C24H21F3N6O3
SMILEs CCOCCn1cc(C(=O)Nc2ccc(-n3nc(-c4cccnc4)cc3C(F)(F)F)cn2)ccc1=O
InChI InChI=1S/C24H21F3N6O3/c1-2-36-11-10-32-15-17(5-8-22(32)34)23(35)30-21-7-6-18(14-29-21)33-20(24(25,26)27)12-19(31-33)16-4-3-9-28-13-16/h3-9,12-15H,2,10-11H2,1H3,(H,29,30,35)
Molecular weight 498.16 Da
AlogP 3.798600000000002
HBond acceptors 9
HBond donors 1
Atoms 57

Vendors

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Expert Reviews

by SERP
(on 3 Jul 2020)
Cellular Use Rating
In Model Organisms
BI-1935 is a potent and selective small-molecule inhibitor of soluble epoxide hydrolase (sEH). Its activity is demonstrated by both in vitro (biochemical binding assay h-sEH = IC50 of 7 nM) and cellular...
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