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BI-1915 | BI-1915 : Inhibitor of CTSS
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CTSS
  • Kd:31 nM
  • IC50:17 nM
  • IC50:2.8 nM
Inhibitor
1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Selectivity within target family: IC50 [µM]: CTSK ( > 10) , CTSL ( > 30) , CTSB ( > 10) Reaction Bio ...

Potency
Cellular
In Vitro

CTSS

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1016/j.bmcl.2012.09.054

Negative Control Compounds

CANSAR4213492
Notes: BI-1920: CTSS binding (SPR): Kd = 272 nM; CTSS inhibition (luminescent based enzymatic assay): IC50 > 20 µM; Eurofins Cerep SafetyScreen44 at 10 µM: clean

Chemical Information

Molecular Formula C21H37N5O3
SMILEs CCC(C)(C)CC[C@H](NC(=O)N1CCOCC1)C(=O)NC1(C#N)CCN(C)CC1
InChI InChI=1S/C21H37N5O3/c1-5-20(2,3)7-6-17(23-19(28)26-12-14-29-15-13-26)18(27)24-21(16-22)8-10-25(4)11-9-21/h17H,5-15H2,1-4H3,(H,23,28)(H,24,27)/t17-/m0/s1
Molecular weight 407.29 Da
AlogP 1.7173800000000015
HBond acceptors 8
HBond donors 2
Atoms 66

Expert Reviews

No SERP comments found for BI-1915

Probe BI-1915 is in the process of SERP review.

Please continue to check back for new reviews and commentary.