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BCX-3607 | BCX-3607 Inhibitor of FVII
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
F7
  • IC50:4 nM
  • IC50:26 nM
    Inhibitor
    --

    Selectivity

    In Vitro Selectivity Assessment
    Potency Assay Off-Target:
    Selectivity was evaluated sampling BCX-3607 against human proteases, with the selectivity ratio, pro ...

    Potency
    Cellular
    In Vitro

    F7

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1016/j.ejmech.2025.117708

    In Vivo Validations

    Rat
    Dose: 1 mg/Kg
    Route of delivery: Intravenous
    Plasma half life: 2.60 h
    Systemic clearance: 0.72 mL/min/Kg
    Cmax: 21,911 ng/mL
    Tmax: 0.083 h
    Area Under the Curve:: 23,328 h∗ng/mL
    Volume of Distribution at Steady-State: 0.12 mL/kg

    DOI Reference: 10.1016/j.ejmech.2025.117708

    Dose: 5 mg/Kg
    Route of delivery: Oral
    Plasma half life: 5.25 h
    Cmax: 47 ng/mL
    Tmax: 4.20 h
    Area Under the Curve:: 422 h∗ng/mL

    DOI Reference: 10.1016/j.ejmech.2025.117708

    Chemical Information

    Molecular Formula C27H29N5O3
    SMILEs [H]/N=C(\N)c1ccc(NCc2cc(C=C)ccc2-c2ccc(C(=O)NCC(C)C)cc2C(=O)O)nc1
    InChI InChI=1S/C27H29N5O3/c1-4-17-5-8-21(20(11-17)15-31-24-10-7-19(14-30-24)25(28)29)22-9-6-18(12-23(22)27(34)35)26(33)32-13-16(2)3/h4-12,14,16H,1,13,15H2,2-3H3,(H3,28,29)(H,30,31)(H,32,33)(H,34,35)
    Molecular weight 471.23 Da
    AlogP 0.0
    HBond acceptors 8
    HBond donors 6
    Atoms 64

    Expert Reviews

    by SERP
    (on 1 Aug 2025 )
    In Model Organisms
    BCX-3607 is a 4 nM molecular inhibitor of TF FVIIa with a reasonable to good selectivity against related proteases like trypsin, thrombin, FXa or plasmin. The binding and interaction of BCX-3607 and FVIIa...
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