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BAY2666605 | BAY2666605 : Molecular Glue of PDE3A
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
PDE3A
  • IC50:82 nM
  • EC50:1.04 nM
  • IC50:5-550nM
Molecular Glue
less than 100 nM
up to 1µM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
BAY-2666605 tested cleanly against panels of PDE enzymes, ion channels, (including hERG) and CYP iso ...

Potency
Cellular
In Vitro

PDE3A

Mode of Action: Molecular Glue

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acsmedchemlett.4c00336

In Vivo Validations

Mouse
Dose: 4.6 h
Route of delivery: Intravenous

DOI Reference: 10.1021/acsmedchemlett.4c00336

Rat
Dose: 15 h
Route of delivery: Intravenous

DOI Reference: 10.1021/acsmedchemlett.4c00336

Dog
Dose:
Route of delivery: Intravenous
Plasma half life: 13 h

DOI Reference: 10.1021/acsmedchemlett.4c00336

Chemical Information

Molecular Formula C17H12F4N2O2
SMILEs C[C@@H]1OC(=O)NN=C1c1ccc(-c2ccc(F)cc2)c(C(F)(F)F)c1
InChI InChI=1S/C17H12F4N2O2/c1-9-15(22-23-16(24)25-9)11-4-7-13(14(8-11)17(19,20)21)10-2-5-12(18)6-3-10/h2-9H,1H3,(H,23,24)/t9-/m0/s1
Molecular weight 352.08 Da
AlogP 4.343900000000002
HBond acceptors 4
HBond donors 1
Atoms 37

References

Publications

Cross References

canSARChEMBLBindingDB

Expert Reviews

by SERP
(on 10 Jan 2026 )
Cellular Use Rating
In Model Organisms
Molecular glues are compounds that induce proximity between two proteins, typically by stabilizing a low-affinity interaction. BAY 2666605 represents a new class of molecular glues called Velcrins with...
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