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BAY-707 | Inhibitor of NUDT1
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NUDT1
  • IC50:2.3 nM
  • EC50 :7.6 nM
Inhibitor
1 nM to 1 µM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Tm shift assay
Selectivity Assessment Description:
BAY-707 is a selective NUDT1 (MTH1) inhibitor across the Nudix family
In Cell Selectivity Assessment
Selectivity Assessment Description:
high selectivity in an in-house kinase panel comprised of 30 kinases

Potency
Cellular
In Vitro

NUDT1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acschembio.7b00370

In Vivo Validations

Mouse Microsomes, Human Microsomes
Dose: 25 mg/Kg, 250 mg/Kg
Systemic clearance: 0.3 L/h/kg

DOI Reference: 10.1021/acschembio.7b00370

Negative Control Compounds

BAY-604

Orthogonal Probes def

TH588

Chemical Information

Molecular Formula C15H20N4O2
SMILEs CCNC(=O)c1cc2c(N3CCOC[C@@H]3C)ccnc2[nH]1
InChI InChI=1S/C15H20N4O2/c1-3-16-15(20)12-8-11-13(4-5-17-14(11)18-12)19-6-7-21-9-10(19)2/h4-5,8,10H,3,6-7,9H2,1-2H3,(H,16,20)(H,17,18)/t10-/m0/s1
Molecular weight 288.16 Da
AlogP 1.5376999999999998
HBond acceptors 6
HBond donors 2
Atoms 41

References

Publications

Cross References

SGC additional analysis

Vendors

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Expert Reviews

by SERP
(on 28 Jun 2020 )
Cellular Use Rating
BAY-707 is a potent inhibitor of the NUTD1 (MHT1) hydrolase. It was selective across the Nudix family. However, additional selectivity data outside the Nudix family has not been published. Therefore,...
by SERP
(on 7 Sept 2021 )
Cellular Use Rating
In Model Organisms
BAY-707 is a potent, selective NUDT1 inhibitor that demonstrates enzymatic inhibition in vitro, and cellular target engagement in cells using CETSA. It does not demonstrate broad anti-cancer activity...
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