Chemical Probes logo
BAY-386 | BAY-386 : Antagonist of F2R
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
F2R
  • IC50:56 nM
  • IC50:10 nM
Antagonist
100 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Selectivity within target family: F2RL3 (PAR4): Functional cellular assay (HEK cells) IC50 > 10 µM ( ...

Potency
Cellular
In Vitro

F2R

Mode of Action: Antagonist

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.7554/eLife.34311

In Vivo Validations

rat, dog and cynomolgus
Dose:
Route of delivery: Oral

DOI Reference: 10.7554/eLife.34311

Negative Control Compounds

BAY-448
Notes: Functional cellular assays (HEK cells): > 1,000 times less active on F2R (IC50 >10 µM) and F2RL3 (IC50 >> 5 µM); Binding assay (platelet membranes): IC50 > 10 µM); Eurofins-Cerep cellular and nuclear receptor functional assay screen (25) at 10 µM: clean; Clean GPCR scan

Chemical Information

Molecular Formula C22H25F3N4O5S
SMILEs O=C(N1CCS(=O)(=O)CC1)N1C[C@H](c2ccc(OC(F)(F)F)cc2)C[C@H](c2nc(C3CC3)no2)C1
InChI InChI=1S/C22H25F3N4O5S/c23-22(24,25)33-18-5-3-14(4-6-18)16-11-17(20-26-19(27-34-20)15-1-2-15)13-29(12-16)21(30)28-7-9-35(31,32)10-8-28/h3-6,15-17H,1-2,7-13H2/t16-,17+/m1/s1
Molecular weight 514.15 Da
AlogP 0.0
HBond acceptors 9
HBond donors --
Atoms 60

Expert Reviews

by SERP
(on 28 Jun 2022 )
Cellular Use Rating
( The reviewer did not leave any comments )
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria