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AZD9496 | AZD9496 : ESR1 antagonist
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
ESR1
  • pIC50:9.17 (0.8 nm)
  • pIC50:9.86 (0.11 nM) ER downregulation; 9.55 (0.28 nM) PR antagonism; 10.4 (0.04 nM) anti-proliferation
Antagonist
< 10 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
High selectivity of AZD9496 over other tested nuclear hormone receptors: androgen receptor (AR), ...
In Cell Selectivity Assessment
Selectivity Assessment Description:
No significant growth inhibition was seen in any ER− cell lines (EC50 &gt; 10 μmol/L) in contrast ...

Potency
Cellular
In Vitro

ESR1

Mode of Action: Antagonist

Structure-Activity-Relationship data available? No

In Vivo Validations

Rat (R), Mouse (M), Dog (D)
Dose: 5-100 mg/Kg
Route of delivery: Intravenous, Oral
Systemic clearance: 1 (R), 43 (M), 0.28 (D) ml/min/Kg

Reference: --

Chemical Information

Molecular Formula C25H25F3N2O2
SMILEs C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(/C=C/C(=O)O)cc2F)N1CC(C)(C)F
InChI InChI=1S/C25H25F3N2O2/c1-14-10-17-16-6-4-5-7-20(16)29-23(17)24(30(14)13-25(2,3)28)22-18(26)11-15(12-19(22)27)8-9-21(31)32/h4-9,11-12,14,24,29H,10,13H2,1-3H3,(H,31,32)/b9-8+/t14-,24-/m1/s1
Molecular weight 442.19 Da
AlogP 0.0
HBond acceptors 4
HBond donors 2
Atoms 57
PAINS * Yes

* This is an automated alert only, and may not necessarily indicate an issue with this probe. ( Learn more about PAINS )

References

Publications

    Cross References

    canSARChEMBLBindingDBPDBPubMed

    Vendors

    Note: This is not an exhaustive list and does not indicate endorsement by the portal.

    Expert Reviews

    by SERP
    (on 7 Jul 2021 )
    Cellular Use Rating
    In Model Organisms
    ( The reviewer did not leave any comments )
    by SERP
    (on 27 Jul 2021 )
    Cellular Use Rating
    In Model Organisms
    The compound AZD9496 was the lead candidate for orally bioavailable selective estrogen receptor downregulator (SERD) with equivalent potency and preclinical pharmacology to the intramuscular SERD fulvestrant....
    by SERP
    (on 6 Sept 2021 )
    Cellular Use Rating
    In Model Organisms
    ( The reviewer did not leave any comments )
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria