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AZD8055 | AZD8055 : ATP competitive inhibitor of MTOR
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MTOR
  • IC50:0.13 ± 0.05 nM
  • IC50:0.8 ± 0.2 nM
  • Ki:1.3nM
  • IC50:24 ± 9 nM
  • IC50:27 ± 3 nM
  • INH:1 µM
  • Activity:1 µM
ATP competitive
1 µM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Within target family: AZD8055 showed excellent selectivity (∼1,000-fold) against all class I phosph ...

Potency
Cellular
In Vitro

MTOR

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? No

DOI Reference: 10.1158/0008-5472.CAN-09-1751

In Vivo Validations

Mouse
Dose: 2.5 and 10 mg/Kg
Route of delivery: Oral

DOI Reference: 10.1158/0008-5472.CAN-09-1751

Orthogonal Probes def

AZD2014
Rapamycin
eCF309

Chemical Information

Molecular Formula C25H31N5O4
SMILEs COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1CO
InChI InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1
Molecular weight 465.24 Da
AlogP 0.0
HBond acceptors 9
HBond donors 1
Atoms 65

Vendors

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Expert Reviews

by SERP
(on 12 May 2023 )
Cellular Use Rating
In Model Organisms
( The reviewer did not leave any comments )
by SERP
(on 14 May 2023 )
Cellular Use Rating
( The reviewer did not leave any comments )
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