Chemical Probes logo
AZD8055 | AZD8055 : ATP competitive inhibitor of MTOR
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

More...

Targets Biochemical/Biophysical Potency Cellular Potency
MTOR
  • IC50:0.13 ± 0.05 nM
  • IC50:0.8 ± 0.2 nM
  • Ki:1.3nM
  • IC50:24 ± 9 nM
  • IC50:27 ± 3 nM
  • INH:1 µM
  • Activity:1 µM
ATP competitive
1 µM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Within target family: AZD8055 showed excellent selectivity (∼1,000-fold) against all class I phosph ...

Potency
Cellular
In Vitro

MTOR

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? No

DOI Reference: 10.1158/0008-5472.CAN-09-1751

In Vivo Validations

Mouse
Dose: 2.5 and 10 mg/Kg
Route of delivery: Oral

DOI Reference: 10.1158/0008-5472.CAN-09-1751

Orthogonal Probes def

AZD2014
Rapamycin
eCF309

Chemical Information

Molecular Formula C25H31N5O4
SMILEs COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1CO
InChI InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1
Molecular weight 465.24 Da
AlogP 0.0
HBond acceptors 9
HBond donors 1
Atoms 65

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the portal.

Expert Reviews

by SERP
(on 12 May 2023)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
by SERP
(on 14 May 2023)
Cellular Use Rating
(The reviewer did not leave any public comments)
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria