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AZD3293 | AZD3293 : Inhibitor of BACE1, BACE2
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
BACE1
  • Ki:0.4 nM
  • IC50:0.6 nM
  • T 1/2:9 h
  • IC50:0.8 nM
BACE2
  • Ki:0.8 nM
  • IC50:0.9 nM
    Inhibitor
    up to 100 nM

    Selectivity

    In Vitro Selectivity Assessment
    Potency Assay Off-Target:
    Selective against hCathepsin D (Ki 3867 nm/ IC50 16100 nM) and gamma-Secretase Notch Cleavage (IC50 ...

    Potency
    Cellular
    In Vitro

    BACE1

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.3233/JAD-150834

    BACE2

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.3233/JAD-150834

    Chemical Information

    Molecular Formula C26H28N4O
    SMILEs CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1
    InChI InChI=1S/C26H28N4O/c1-4-5-18-12-21(16-28-15-18)19-6-7-20-14-25(10-8-22(31-3)9-11-25)26(23(20)13-19)29-17(2)24(27)30-26/h6-7,12-13,15-16,22H,8-11,14H2,1-3H3,(H2,27,30)/t22-,25-,26-/m0/s1
    Molecular weight 412.23 Da
    AlogP 0.0
    HBond acceptors 5
    HBond donors 2
    Atoms 59

    References

    Publications

    Cross References

    canSARChEMBLBindingDBBindingDB

    Expert Reviews

    by SERP
    (on 31 Jul 2024 )
    Cellular Use Rating
    ( The reviewer did not leave any comments )
    by SERP+
    (on 23 Sept 2024 )
    Cellular Use Rating
    AZD3293 is a highly potent inhibitor of both BACE1 (IC50: 0.6 nM in vitro) and BACE2 AM-6494 (IC50: 0.9 nM in vitro) with high selectivity over hCathepsin D (IC50: 16100 nM) and hERG (IC50: 4700nM). A...
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