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AVL-292 | AVL-292 : Covalent inhibitor of BTK
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
BTK
  • Kinact/KI:7.69 x 10^4 per M per sec
  • EC50:8 nM
Covalent Inhibitor
Up to 100 nM

Selectivity

In Vitro Selectivity Assessment

Potency: IC50(app) - BMX 0.7 nM, ITK 36 nM, TEC 6.2 nM, TXK 8.9 nM

Potency Assay Off-Target:
High selectivity was noted against kinases with a comparable Cys (EGFR, ITK, JNK3). CC-292 was run ...

Potency
Cellular
In Vitro

BTK

Mode of Action: Covalent Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1124/jpet.113.203489

In Vivo Validations

Mouse
Dose: 50 mg/kg
Route of delivery: Oral
Organ of interest (O): spleen, joint
Target engagement assay: In the spleen, BTK occupancy was measured.

Reference: --

Orthogonal Probes def

CGI1746
GDC-0834

Chemical Information

Molecular Formula C22H22FN5O3
SMILEs C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCOC)cc3)ncc2F)c1
InChI InChI=1S/C22H22FN5O3/c1-3-20(29)25-16-5-4-6-17(13-16)26-21-19(23)14-24-22(28-21)27-15-7-9-18(10-8-15)31-12-11-30-2/h3-10,13-14H,1,11-12H2,2H3,(H,25,29)(H2,24,26,27,28)
Molecular weight 423.17 Da
AlogP 0.0
HBond acceptors 8
HBond donors 3
Atoms 53

References

Publications

Cross References

canSARChEMBLBindingDB

Vendors

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Expert Reviews

by SERP
(on 22 May 2016 )
Cellular Use Rating
This probe inhibits both BTK and EGFR, similar to ibrutinib. In cell based assays AVL-292 appears to have additional targets as it is cytotoxic to endothelial cells at 10 uM and active at 300 nM in...
by SERP
(on 2 Jun 2016 )
Cellular Use Rating
In Model Organisms
AVL-292 is a covalent inhibitor of BTK (IC50apparent <0.5 nM). Selectivity was >1000-fold based on IC50 determination against a panel of 47 kinases, and in two larger kinome panels (386 and 205 kinases,...
by SERP
(on 12 Apr 2017 )
Cellular Use Rating
In Model Organisms
AVL-292 is a covalent BTK inhibitor. Some selectivity data was provided demonstrating that the compound did inhibit other kinases under 100 nM (BMX, ITK, TEC, TXK) in a biochemical assay format. The...
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