Atirmociclib |
Atirmociclib : Inhibitor of CDK4, CDK6
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| CDK4 |
|
|
Inhibitor
up to 1 uM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
Biochemical assays with 265 recombinant kinases in in vitro enzymatic assays (CARNA) by 1 μM atirmoc ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
A set of 25 cell lines were tested with Atirmociclib and the following were found sensitive to treat ...
In Vitro Selectivity Assessment
Potency Assay Off-Target:
in a biochemical Assay using recombinant CDK6- cyclin D3, CDK6 activity was 23 nM
In Cell Selectivity Assessment
Potency Assay Off-Target:
IC50 of 2881 nM, assessing phosphorylation of RB1 at serine 807/811 from CDK4 independent human pri ...
Potency Cellular
In Vitro
CDK4
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? No
DOI Reference: 10.1016/j.ccell.2025.02.006
Chemical Information
| Molecular Formula | C22H27ClFN5O3 |
| InChI | InChI=1S/C22H27ClFN5O3/c1-11(2)29-16-8-12(7-14(24)19(16)27-20(29)22(3,4)31)18-13(23)9-25-21(28-18)26-15-5-6-32-10-17(15)30/h7-9,11,15,17,30-31H,5-6,10H2,1-4H3,(H,25,26,28)/t15-,17-/m1/s1 |
| Molecular weight | 463.18 Da |
| AlogP | 0.0 |
| HBond acceptors | 8 |
| HBond donors | 3 |
| Atoms | 59 |