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ARS-1620 | Covalent Inhibitor of KRAS (Mutant:G12C)
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
KRAS (Mutant:G12C)
  • kobs/[I]:1,100 ± 200 M−1 s−1
  • IC 50:120 nM
Covalent Inhibitor
0.3 - 3.0 uM

Selectivity

In Cell Selectivity Assessment
Selectivity Assessment Description:
Proteome and Transcriptome Profiling the Functional Selectivity of ARS-1620 for KRASG12C and Associa ...

Potency
Cellular
In Vitro

KRAS (Mutant:G12C)

Mode of Action: Covalent Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1016/j.cell.2018.01.006

In Vivo Validations

Mouse
Dose: 50 mg/Kg, 200 mg/Kg
Route of delivery: Oral
Plasma half life: 2.5 h (Mouse), 3.5 h (Human)

DOI Reference: 10.1016/j.cell.2018.01.006

Negative Control Compounds

R-atropisomer

Orthogonal Probes def

SOTORASIB
MRTX-849

Chemical Information

Molecular Formula C21H17ClF2N4O2
SMILEs C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4c(O)cccc4F)c(Cl)cc23)CC1
InChI InChI=1S/C21H17ClF2N4O2/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17(19(24)20(12)25-11-26-21)18-14(23)4-3-5-15(18)29/h2-5,10-11,29H,1,6-9H2
Molecular weight 430.10 Da
AlogP 3.768600000000003
HBond acceptors 6
HBond donors 1
Atoms 47

References

Publications

Cross References

canSARChEMBLBindingDBPubMedPubMed

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the portal.

Expert Reviews

by SERP
(on 15 Feb 2024 )
Cellular Use Rating
In Model Organisms
Less potent than later KRAS(G12C) inhibitors
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria