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ARCC-4 | Degrader (PROTAC) of AR
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
AR
    • DC50, Dmax, IC50:5 nM; 98%; 36 nM (IC50)
    Degrader (PROTAC)
    > 50 nM

    Selectivity

    In Cell Selectivity Assessment
    Selectivity Assessment Description:
    @ 1 uM ARCC-4 had no effect on glucocorticoid receptor and estrogen receptor levels, while there ...

    Potency
    Cellular
    In Vitro

    AR

    Mode of Action: Degrader (PROTAC)

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1038/s42003-018-0105-8

    Negative Control Compounds

    cpd 3

    Orthogonal Probes def

    ARD-266

    Chemical Information

    Molecular Formula C53H56F3N7O7S2
    SMILEs Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCOc2ccc(-c3ccc(N4C(=S)N(c5ccc(C#N)c(C(F)(F)F)c5)C(=O)C4(C)C)cc3)cc2)C(C)(C)C)cc1
    InChI InChI=1S/C53H56F3N7O7S2/c1-32-45(72-31-59-32)36-11-9-33(10-12-36)28-58-47(66)43-26-40(64)29-61(43)48(67)46(51(2,3)4)60-44(65)30-69-23-7-8-24-70-41-21-16-35(17-22-41)34-13-18-38(19-14-34)63-50(71)62(49(68)52(63,5)6)39-20-15-37(27-57)42(25-39)53(54,55)56/h9-22,25,31,40,43,46,64H,7-8,23-24,26,28-30H2,1-6H3,(H,58,66)(H,60,65)/t40-,43+,46-/m1/s1
    Molecular weight 1023.36 Da
    AlogP 8.577400000000006
    HBond acceptors 14
    HBond donors 3
    Atoms 128

    References

    Publications

    Cross References

    canSARChEMBL

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    Expert Reviews

    by SERP
    (on 9 Feb 2021 )
    Cellular Use Rating
    ( The reviewer did not leave any comments )
    by SERP+
    (on 6 Feb 2026 )
    Cellular Use Rating
    This is a good degrader, but some data are missing that should be presented to confirm the MoA. For example, knockdown of AR, or competition experiments should be provided. In particular, the lack of proteomics...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria